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COMPUTATIONAL TOOL FOR PRE-SURGICAL EVALUATION OF PATIENTS WITH MEDICALLY REFRACTORY EPILEPSY
专利权人:
发明人:
Sridevi Sarma,Bhaskar Chennuri,John T. Gale,Jorge Alvaro Gonzalez-Martinez
申请号:
US15089058
公开号:
US20160287118A1
申请日:
2016.04.01
申请国别(地区):
US
年份:
2016
代理人:
摘要:
A method of identifying an epileptogenic zone of a brain includes receiving a plurality of electrical signals from a plurality of surgically implanted electrodes, calculating components of an adjacency matrix, calculating eigenvectors from the adjacency matrix, and selecting an eigenvector having a largest eigenvalue. The method includes assigning an integer rank to each component of the eigenvector, sliding the time window by a time increment and repeating the immediately preceding steps a plurality of times. The method includes normalizing each rank signal, extracting a multidimensional feature vector from each normalized signal, projecting each multidimensional feature vector onto a reduced dimensionality space, and receiving a plurality of training data points represented in the reduced dimensionality space. The method includes calculating grid weights for each feature vector, and assigning a numerical value to each electrode as an indication of whether the electrode is in an epileptogenic zone of the brain.
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