PROBLEM TO BE SOLVED: To provide a nanoparticle for iontophoresis having a high percutaneous absorption rate.SOLUTION: The manufacturing method includes a dispersion step of obtaining a dispersion product of the positively or negatively charged nanoparticle by containing a delivery matter and the biodegradable polymer after mixing, in the presence of the delivery matter, a solution containing the biodegradable having a dissociative group and a first solvent as a good solvent for the biodegradable polymer with a second solvent that is compatible with the first solvent, Lewis acid or base of the first solvent, and a poor solvent for the biodegradable polymer.COPYRIGHT: (C)2013,JPO&INPIT【課題】経皮吸収率の高いイオントフォレシス用のナノ粒子を提供する。【解決手段】解離性基を有する生分解性ポリマー、及び前記生分解性ポリマーの良溶媒である第一の溶剤を含む溶液と、前記第一の溶剤と相溶性であり、前記第一の溶剤のルイス酸又はルイス塩基であり、且つ前記生分解性ポリマーの貧溶媒である第二の溶剤とを、被送達物の存在下で混合して、前記被送達物及び前記生分解性ポリマーを含有し正又は負に帯電したナノ粒子の分散物を得る分散工程を含む、イオントフォレシス用ナノ粒子の製造方法。【選択図】なし
