Fluid coupling devices for connecting to and disconnecting from a male barbed fitting to provide a continuous flow path or a flow termination point, include a frame and an elastomeric sealing material disposed about and at least partially encapsulating the frame. The frame can have a first end including a connecting element. The frame can also have a second end including a ring that has two inwardly directed, radial locking tabs. At least a portion of the sealing material can define a thru lumen. At least a portion of the thru lumen can include a tapered, inner portion configured to create a sealed connection with a male barbed fitting. The second end of the fluid coupling device, when compressed, can deflect the locking tabs in a radially outward direction for releasing the male barbed fitting.
