MATHIESEN, JACOB,NIELSEN, CARSTEN MARTINI,OLSEN, PEDER MOHR,BERTELSEN, POUL EGON
申请号：
CA2581703
公开号：
CA2581703C
申请日:
2005.05.24
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention relates to a particulate material and a solid dosageform notably tablets comprising a regularly shaped calcium-containing compoundsuch as a calcium salt as a therapeutically and/or prophylactically activesubstance and a pharmaceutically acceptable sugar alcohol such as, e.g.,sorbitol and/or isomalt that has a micro structure as evidenced by SEM. Theinvention also relates to a process for the preparation of the particulatematerial and solid dosage form. The process involves agglomeration of thecalcium-containing compound and the pharmaceutically acceptable sugar alcoholby means of roller compaction. The particulate material obtained by rollercompaction is suitable for use in the further processing of the particulatematerial into e.g. tablets such as chewing tablets.
