PURPOSE: A method for manufacturing carbapenem antibiotic compounds for intravenous administration and intramuscular administration is provided to be used commercially.CONSTITUTION: A method for manufacturing a solution of a compound of chemical formula I, or pharmaceutically acceptable salts thereof, hydrate, or solvate thereof comprises: a step of dissolving carbon salt source and base in a diluents at 0-25 Deg.C. to prepare a first solution and a step of mixing the compound of chemical formula I with a first solution at -5 to 25 Deg.C. to prepare a solution. The carbon salt source is carbon dioxide, sodium bicarbonate, potassium bicarbonate, sodium carbonate, potassium carbonate, calcium carbonate, cesium carbonate, magnesium carbonate, lithium carbonate, or a mixture thereof.COPYRIGHT KIPO 2012본 발명은 정맥투여 및 근육내 투여에 유용한 카르바페넴 항생제 화합물의 제조 방법에 관한 것이다.
