VARIANTS D'INHIBITEUR TISSULAIRE DE LA MÉTALLOPROTÉINASE DE TYPE TROIS (TIMP-3), COMPOSITIONS ET PROCÉDÉS

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专利权人:

Amgen; Inc

发明人:

申请号：

EP19185328.2

公开号：

EP3575316A1

申请日:

2015.08.26

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

The application relates to variants or muteins of tissue inhibitor of metalloproteinase 3 (TIMP-3), especially variants thereof where certain amino acid residues are substituted in order to introduce N-linked glycosylation sites (N-X-T or N-X-S). Some of the variants made improve the half-life and pharmacokinetic or pharmacodynamic properties and facilitate production and purification. In particular, the mutein contain the pairs: K45N/V47T； K50N/V52T； P56N/G58T； H78N/Q80T； K94N/E96T； D110N/K112T； the substitutions R138T； G173T and, optionally, also F57N, leading to at least two engineered N-linked glycosylation sites.

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