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2 Analysis, preparation and use of pridopidina
专利权人:
TEVA PHARMACEUTICAL INDUSTRIES LTD.
发明人:
SCHMIDT MALLE,MALLE PÄRI,LAOS MARIT,MAASALU ANTS,KALJUSTE KALLE
申请号:
UY36192
公开号:
UY36192A
申请日:
2015.06.26
申请国别(地区):
UY
年份:
2016
代理人:
摘要:
This invention provides an isolated compound having the following structure: a salt thereof. The invention also provides a process for preparing 4- (3- (methylsulfonyl) phenyl) - 1-propylpiperidin-4-ol, 1- (3,3-bis (3- (methylsulfonyl) phenyl) propyl) -4- (3 - (methylsulfonyl) phenyl) piperidone, 1,4-bis ((3- (1-propylpiperidin-4-yl) phenyl) sulfonyl) butane, (3R, 4S) -4- (3- (methylsulfonyl) phenyl) -1 -propylpiperidin-3-ol, 4- (3- (methylsulfonyl) phenyl) -1-propylpiperidine, 1- (2-methylpentyl) -4- (3- (methylsulfonyl) phenyl) piperidine, 4- (3 - (methylsulfinyl) phenyl) -1-propyl-1,2,3,6-tetrahydropyridine,And 4 - (3 - (methylthio) phenyl) - 1-propyl-1,2,3,6-tetrahydropyridine. The invention also provides an impurity or salt as a reference standard for the detection of trace impurities in pharmaceutical ingredients containing pridopidine or acceptable salts on drugs. The invention also provides a process for producing IRS pharmacological products.The polypeptide includes obtaining five kinds of pridopidine pharmacological substances and mixing them with enough precursor chemicals to provide pridopidine pharmacological products. The invention also provides a process for the production of pridopidina pharmacological products. The invention also provides a procedure for the distribution of pridopidina pharmacological products.Esta invención provee un compuesto aislado que tiene la siguiente estructura: una sal del mismo. La invención también provee un proceso para preparar 4-(3-(metilsulfonil)fenil)- 1-propilpiperidin-4-ol, 1-(3,3-bis(3-(metilsulfonil)fenil)propil)-4-(3- (metilsulfonil)fenil)piperidona, 1,4-bis((3-(1-propilpiperidin-4-il)fenil)sulfonil)butano, (3R,4S)-4-(3-(metilsulfonil)fenil)-1-propilpiperidin-3-ol, 1-óxido de 4-(3- (metilsulfonil)fenil)-1-propilpiperidina, 1-(2-metilpentil)-4-(3- (metilsulfonil)fenil)piperidina, 4-(3-(metilsulfinil)fenil)-1-propil-1,2,3,6-tetrahidropiridina, y 4-(3-(metilsulfonil)fenil)-1-propil-1,2,3,6-tetrahidropiridina. Esta
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