abstract the present invention relates to novel substituted bicyclic methyl amine derivatives which are useful as sphingosine-1-phosphate receptors modulators and useful for treating a wide variety of disorders associated with modulation of sphingosine-1-phosphate receptors. Abstract Patented Bicyclic Methyl Amine Derivatives as Modulators of Es-Finfgosine-1 Phosphate Receptors. The present invention relates to novel substituted bicyclic phenyl methyl amine derivatives of formula (I), wherein a, 11,12, r 1 to r 7 and a to c are as defined according to claim 1, their compositions and its use in the treatment of diseases related to sphingosine-1-phosphate receptor modulation.abstract the present invention relates to novel substituted bicyclic methyl amine derivatives which are useful as sphingosine-1-phosphate receptors modulators and useful for treating a wide variety of disorders associated with modulation of sphingosine-1-phosphate receptors. tradução resumo patente de invenção: "derivados de metil amina bicíclicos substituídos como moduladores dos receptores de es-finfgosina-1 fosfato". a presente invenção refere-se a novos derivados de metil amina fenil bicíclicos substituídos de fórmula (i), em que a, l1, l2, r1 a r7 e a até c são como definidos de acordo com a reivindicação 1, as suas composições e o seu uso no tratamento de doenças relacionadas com a modulação dos receptores de esfingosina-1-fosfato.
