Systems, devices, and methods for treating a patient are disclosed. The systems can include a cryotherapy apparatus for selectively treating targeted tissue. The cryotherapy apparatus includes one or more stress relief couplings located along a conduit to help keep an applicator positioned at a treatment site without significant rotational torque being imparted to the applicator by the conduit so that the applicator does not tend to move relative to patient skin during a tissue treatment. The stress relief couplings can include swivel connectors and clamps that cooperate to minimize or limit a rotational force exerted on the applicator by the conduit after the applicator is applied to the patient's skin.
