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SYNTHÈSE DE DULOXÉTINE ET/OU DE SES SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CELLE-CI
专利权人:
KRKA; D.D.; Novo Mesto
发明人:
申请号:
EP11714279.4
公开号:
EP2558455B1
申请日:
2011.04.13
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The invention describes an improved process for the synthesis of duloxetine and/or pharmaceutically acceptable salts thereof enabling preparation of duloxetine and/or pharmaceutically acceptable salts thereof with high chemical and enatiomeric purity. The process includes addition of an organic acid in the phase of formation of a duloxetine salt with an acid, preferably in the form of hydrochloride, and optionally in the phase of recrystallization of the formed duloxetine salt, wherein an organic acid is preferably selected from the group comprising formic acid, acetic acid, propanoic acid, butanoic acid or any mixtures thereof, more preferably acetic acid.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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