BODHURI, PRABHUDAS,GORIN, BORIS,GREEN, MELANIE R. A.,WEERATUNGA, GAMINI
申请号：
CA3058682
公开号：
CA3058682A1
申请日:
2018.04.17
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides processes for the preparation of Acalabrutinib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for coupling of a compound of Formula (5) and 2-butynoic acid in the presence of Carbodiimide (8) to afford Acalabrutinib (1).
