COMPOSITION PHARMACEUTIQUE COMPORTANT DE L'ISOBUTYRATE DE (2R,3S,4R,5R)-5-(4-AMINO-2-OXO-2H-PYRIMIDIN-1-YL)-2-AZIDO-3,4-BIS(ISOBUTYRYLOXY)-TETRAHYDROFURAN-2-YLMETHYLE
BIRUDARAJ, KONDAMRAJ,BRANDL, MICHAEL THOMAS,HEGDE, SHRIDHAR,SANA, FELIX,STEFANIDIS, DIMITRIOS
申请号：
CA2682638
公开号：
CA2682638C
申请日:
2008.03.18
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to a method of forming granules of (2R,3S,4R,5R)-5-(4-amino-2-oxo-2 H -pyrimidin-1-yl)-2-azido-3,4-bis -iso-butyryloxy-tetrahydro-furan-2-ylmethyl isobutyrate； hydrochloride salt (I), comprising mixing I, with a granulating amount of a granulating liquid, and a polyethylene glycol (PEG)/polypropylene glycol (PPG) block copolymer as a binder and solubility enhancer to form wet granules which are then dried to remove the granulating liquid.
