AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH;NATIONAL UNIVERSITY OF SINGAPORE
发明人:
TEO, Chong Kok,CHOO, Andre Boon Hwa,CHNG, Wee Joo
申请号：
WO2018SG50158
公开号：
WO2018182529(A1)
申请日:
2018.03.29
申请国别(地区):
世界知识产权组织国际局
年份:
2018
代理人:
摘要：
An antigen-binding protein, or an antigen-binding fragment thereof that binds to a Lewis X type glycan on SLAMF7, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GYTFTSYWIH; a VHCDR2 having the amino acid sequence EINPSNGRTNFNEKFKN and a VHCDR3 having the amino acid sequence VDYDEAY; and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence RSSKSLLHSNGITYLY, a VLCDR2 having the amino acid sequence QMSNLAS, and a VLCDR3 having the amino acid sequence AQNLELWT is provided. Methods of using the antibody for detecting or treating cancer, and a kit comprising the antibody are also provided.
