The invention relates to 1-(3-sulfonylphenyl)-3-(cyclopent-2-en-1- yl)urea derivatives, and their use in treating or preventing diseases and conditions mediated by the CXCR2 receptor. In addition, the invention relates to compositions containing the derivatives and processes for their preparation.本發明關於1-(3-磺醯基苯基)-3-(環戊-2-烯-1-基)脲衍生物及其用於治療或預防CXCR2受體所調控之疾病與症狀的用途。此外,本發明關於含有該衍生物的組成物及其製備方法。