The present invention relates to vesicles derived from Proteus bacteria and their uses. Compared to normal humans, the present inventors have cancer patients such as gastric cancer, colon cancer, liver cancer, biliary tract cancer, pancreatic cancer, lung cancer, breast cancer, ovarian cancer, asthma, chronic obstructive pulmonary disease (COPD), atopy dermatitis, etc. Allergies-respiratory diseases, myocardial infarction, myocardial diseases, atypical angina, cardiovascular diseases such as atrial fibrillation, metabolic diseases such as diabetes, and neuro-psychiatric diseases such as Parkinson's disease and depression. The number of follicles is significantly reduced, and it has been experimentally confirmed that the vesicles suppress the secretion of inflammation mediators by pathogenic vesicles and at the same time exhibit anticancer efficacy. As a result, the Proteus bacterium according to the present invention was confirmed. Origin vesicles are used to develop diagnostic methods for cancer, cardiovascular disease, metabolic disease, and neuro-psychiatric disease, allergy-respiratory disease and inflammatory bowel disease, and compositions for prevention, treatment and / or improvement. It is expected that it can be usefully used for the purpose. FIG. 21b.本発明は、プロテウス属細菌由来小胞及びその用途に関する。本発明者らは、正常ヒトに比べて胃癌、大腸癌、肝癌、胆道癌、膵臓癌、肺癌、乳癌、卵巣癌などの癌患者、喘息、慢性閉塞性肺疾患（ＣＯＰＤ）、アトピー皮膚炎などのアレルギー－呼吸器疾患、心筋梗塞、心筋病症、異型狭心症、心房細動などの心血管疾患、糖尿病などの代謝疾患、及びパーキンソン病、うつ病などの神経－精神疾患患者のサンプルに前記小胞が有意に減少しており、前記小胞は、病原性小胞による炎症媒介体の分泌を抑制すると同時に、抗癌効能を示すことを実験的に確認したところ、本発明によるプロテウス属細菌由来小胞は、癌、心血管疾患、代謝疾患、及び神経－精神疾患、アレルギー－呼吸器疾患及び炎症性腸疾患の診断方法、及び予防、治療及び／又は改善用組成物を開発するための目的で有用に利用され得るものと期待される。【選択図】図２１ｂ
