A triamcinolone acetonide ophthalmic preparation and preparation method thereof. The main components of the preparation in percentage by weight are: 0.05% to 0.5% of triamcinolone acetonide, 0.1% to 0.9% of sodium chloride, 1.0% to 5.0% of hydroxypropyl methyl cellulose, 0.05% to 0.2% of polysorbate 80, and an appropriate amount of buffer solution and sterile purified water. The preparation can also comprise preservative and/or boric acid. The preparation method is as follows: sterilized triamcinolone acetonide and polysorbate 80 are mixed evenly, and an appropriate amount of sterile purified water is added to produce a suspension all components except hydroxypropyl methyl cellulose are added to sterile purified water to obtain a solution after an appropriate amount of dissolution the produced suspension and solution are mixed evenly and sterilized, and then mixed evenly with a hydroxypropyl methyl cellulose solution sterile purified water is added such that sterile purified water accounts for 90% of the liquid volume pH value is adjusted sterile purified water is used to dilute and fix the volume of the solution.本發明涉及一種曲安奈德眼用製劑及其製備方法,該眼用製劑主要組分為曲安奈德0.05~0.5%,氯化鈉0.1~0.9%,羥丙基甲基纖維素1.0~5.0%,聚山梨酯80 0.05~0.2%,緩衝溶液適量和無菌純水,取已滅菌的曲安奈德和聚山梨酯80混勻,加適量無菌純水,製成混懸液,將氯化鈉、乙二胺四乙酸鈣鈉、苯扎溴銨、乙酸、乙酸鈉、硼酸,加無菌純水適量溶解得溶液,然後將所得的混懸液和溶液混勻,100℃滅菌,滅菌後的溶液和羥丙基甲基纖維素溶液混勻,加無菌純水至液體體積的90%;最後用無菌NaOH或HCl溶液調節pH值為5~7,用無菌純水稀釋定容即得眼用製劑,該滴眼劑具有合適的黏度,生物利用度高,對眼部刺激性少等優點。
