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COMPOSITIONS CONCERNANT UNE TOXINE MUTANTE DE CLOSTRIDIUM DIFFICILE ET PROCÉDÉS ASSOCIÉS
专利权人:
Wyeth LLC
发明人:
申请号:
EP19167276.5
公开号:
EP3549949A1
申请日:
2012.04.20
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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