A method for patient specific, real time automatically adjusting at least one of technical exposure factors taken from the group consisting of:- X-ray tube power (kV),- X-ray tube current (mA),- Exposure duration (sec) and- Film speedfor acquiring a radiographic image, the method comprising the following steps:A) A first (scout) acquisition is performed, using pre-defined parameters in a specific anatomical area of a patient;B) A Region Of Interest (ROI) is extracted, and from itC) A grey level histogram of the image pixels is provided;The method provides for the further steps of:D) The histogram of the acquired image is segmented into at least two sectors;E) At least a coefficient is assigned for each sector;F) A weight is assigned to each sector coefficient;G) At least an exposure parameter is computed according to the weights assigned to each sector;then the exposure of the real acquisition is performed with the parameters computed according to the method.