Protein purification methods to reduce acidic species

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专利权人:

发明人:

Natarajan Ramasubramanyan,Lihua Yang,Matthew Omon Herigstad,Hong Yang,Christopher Chumsae

申请号：

US14584492

公开号：

US09346879B2

申请日:

2014.12.29

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of charge variants, aggregates, and fragments of a protein of interest, as well as host cell proteins, present in purified preparations by applying particular chromatography conditions during such protein purification.

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