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Low acidic species compositions
专利权人:
发明人:
Natarajan Ramasubramanyan,Lihua Yang,Matthew Omon Herigstad,Hong Yang,Christopher Chumsae
申请号:
US13829989
公开号:
US09334319B2
申请日:
2013.03.14
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of charge variants, aggregates, and fragments of a protein of interest, as well as host cell proteins, present in purified preparations by applying particular chromatography conditions during such protein purification.
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