Compounds of formula (I):whereinX is O or S,R1 is acyl, aldehyde, cycloalkyl, an optionally substituted alkyl, alkenyl or alkynyl,R2 is H, alkyl, hydroxyalkyl, haloalkyl, alkenyl, or alkynyl； substituted alkyl； alkylcarbonyl；R3 and R4 are H, halogen, alkyl, alkenyl, alkynyl, alkoxyl, alkylthio, hydroxyalkyl, haloalkyl, haloalkenyl, or haloalkynyl；or R3 and R4 form an, optionally aromatic or heterocyclic, optionally substituted ring,R5 is H, halogen, trifluoromethyl, —CN, or —NO2；not all of R3, R4, and R5 being H,R6 and R9 are H, halogen, OH； alkyl, hydroxyalkyl, alkoxyl, thioalkyl, haloalkyl, alkenyl, or alkynyl；R7 and R8 are H, halogen, OH, SH； alkoxyl or alkylthio optionally substituted by OH and/or halogen； one of R7 and R8 not being H or halogen； or one of R7 and R8 is a pharmaceutically acceptable ester or thioester grouping,or R6 is C1-3-alkyl or, together with either R1 or R2, represents C1-3 alkylene or alkenylene linking group, optionally substituted by methyl, trifluoromethyl, OH, or halogen,and pharmaceutically acceptable salts and esters thereof, are useful as selective androgen modulators.
