Sven Haferkamp,Roman Gerber Aeschbacher,Miriam Oberholzer,Armine Aramayisyan,David Hambardzumyan,Arsen Sahakyan,Viktorya Rstakyan
申请号：
GB201520346
公开号：
GB2552919A
申请日:
2015.11.18
申请国别(地区):
GB
年份:
2018
代理人:
摘要：
A process for the preparation daclatasvir or a pharmaceutically acceptable salt thereof, wherein the process includes the synthetic step of reacting a compound of Formula (I) with a compound of Formula (II): Wherein LG is a leaving group and Z is a protecting group. The protecting group Z may be selected from Boc, Cbz, Tosyl, Mesyl, Benzyl, Fmoc, substituted acetyl, Benzoyl and Tolyl. A process for the production of amorphous daclatasvir-2 HCl is also provided, comprising the steps of contacting daclatasvir-2 HCl with a pharmaceutically acceptable solvent filtering off the solution or dispersion of the first step and the immediate removal of the solvent from the filtered solution or dispersion of the second step, characterised in that the solvent removal is performed within a timescale of 10 seconds to 5 hours after the filtering step.
