WRIGHT, JEREMY C.,TAMRAZ, WILMA,LEONARD, JOHN J.,GIBSON, JOHN W.,BRANHAM, KEITH E.,SJOBECK, STEFANIA,BOYD, BROOKS,RUBINO, CHRISTOPHER M.
申请号：
CA2903769
公开号：
CA2903769A1
申请日:
2014.03.11
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
A carrier formulation for controlled release of injectable drugs is disclosed. The formulation comprises a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM) like sucrose acetate isobutyrate, a lactic acid-based polymer like poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25°C in one atmosphere. The drug is released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours； 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration； and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti- schizophrenia agent delivered by injection.
