HOFFMANN, MATTHIAS,BISCHOFF, DANIEL,DAHMANN, GEORG,KLICIC, JASNA,SCHAENZLE, GERHARD,WOLLIN, STEFAN LUDWIG MICHAEL,CONVERS-REIGNIER, SERGE GASTON,EAST, STEPHEN PETER,MARLIN, FREDERIC JACQUES,MCCARTHY,
申请号：
CA2843022
公开号：
CA2843022C
申请日:
2012.07.19
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The invention relates to new substituted quinolines of formula (1) wherein R1 is a linear or branched C1-6-alkyl, wherein R1 may optionally be substituted by R3 which is selected from the group consisting of a three-, four-, five-, six- or seven-membered cycloalkl； a five-, six- or seven-membered, saturated heterocycle comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O； and a five- or six-membered heteroaryl comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O； wherein R3 may optionally be substituted further substituted as defined in claim 1 and wherein R2 is selected from the group consisting of halogen, phenyl, a five- or six-membered monocyclic heteroaryl comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O； a bicyclic, nine-, ten- or eleven-membered, either aromatic or non-aromatic, but not fully saturated heterocycle comprising one, two, three or four heteroatoms each independently selected from the group consisting of N, S and O； wherein R2 may optionally be further substituted as defined in claim 1, and their use in the preparation of medicaments for the treatment of disease such as asthma, COPD, allergic rhinitis, allergic dermatitis and rheumatoid arthritis.
