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Condensed heterocyclic derivative, medicinal composition that contains it and its medicinal use
专利权人:
KISSEI PHARMACEUTICAL CO.; LTD.
发明人:
FUSHIMI, NOBUHIKO,YONEKUBO, SHIGERU,MURANAKA, HIDEYUKI,SHIOHARA, HIROAKI,TERANISHI, HIROTAKA,SHIMIZU, KAZUO,ITO, FUMIAKI,ISAJI, MASAYUKI
申请号:
ES04722965
公开号:
ES2383892T3
申请日:
2004.03.24
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A condensed heterocyclic derivative represented by the following general formula (I): wherein R 1 represents a hydrogen atom, a halogen atom, a hydroxy group, an amino group, a mono or di (C 1-6 alkyl) amino group, a C1-6 alkyl group, a C1-6 alkoxy group, a halo group (C1-6 alkyl), a halo group (C1-6 alkoxy), a hydroxy group (C1-6 alkyl), a hydroxy group (C1 alkoxy -6), a mono or di [hydroxy (C 1-6 alkyl)] amino group, a carboxy group, a C 2-7 alkoxycarbonyl group, a carbamoyl group or a carbamoyl group (C 1-6 alkyl); R2 represents a hydrogen atom, a halogen atom or a C1-6 alkyl group; R3 and R4 independently represent a hydrogen atom, a hydroxy group, a halogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a C1-6 alkoxy group, an alkenyloxy group C2-6, a C1-6 alkyl group, a C2-6 alkenylthio group, a halo group (C1-6 alkyl), a halo group (C1-6 alkoxy), a halo group (C1-6 alkylthio), a group hydroxy (C1-6 alkyl), to hydroxy (C2-6 alkenyl), a hydroxy group (C1-6 alkoxy), a hydroxy group (C1-6 alkylthio), a carboxy group, a carboxy group (C1-6 alkyl) , a carboxy group (C2-6 alkenyl), a carboxy group (C1-6 alkoxy), a carboxy group (C1-6 alkylthio), a C2-7 alkoxycarbonyl group, a C2-7- alkoxycarbonyl group (C1-6 alkyl ) substituted, a C2-7- (C2-6 alkenyl) alkoxycarbonyl group, a substituted C2-7- alkoxycarbonyl (C1-6 alkoxy) group, a substituted C2-7- alkoxycarbonyl (C1-6 alkylthio) group, a group C1-6 alkylsulfinyl, a C1-6 alkylsulfonyl group, -UVWN (R5) -zo any era of the following substituents (i) to (xxviii) that may have 1 to 3 substituents selected from the following group of α substituents on the ring; (i) a C6-10 aryl group, (ii) C6-10-O- aryl, (iii) C6-10-S- aryl, (iv) a substituted C6-10- (C1-6 alkyl) group, (v) a substituted C6-10- (C1-6 alkoxy) aryl group, (vi) a substituted C6-10- (C1-6 alkylthio) group, (vii) a heteroaryl group, (viii) heteroaryl-O- , (ix) heteroaryl-S-, (x) a heteroaryl (C1-6 alkyl) group, (xi) a heteroaryl (C1-6 al
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