A cross linking polypeptide comprising an hexameric single chain antibody binding MHC-MAGE complex that induces apoptosis

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专利权人:

Apo-T B.V.

发明人:

Willemsen, Ralph Alexander

申请号：

AU2011353197

公开号：

AU2011353197A1

申请日:

2011.12.22

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

The present invention relates to a polypeptide comprising at least four domains specifically binding to a certain MHC peptide complex, said domains separated by linker amino acid sequences, thereby providing each domain with the capability to bind a separate MHC peptide complex, to a nucleic acid encoding for such a polypeptide, to a vector comprising such a nucleic acid, to a host cell for expression of such a polypeptide, to a pharmaceutical composition comprising such a polypeptide, and to a kit of parts comprising at least two polypeptides according to the invention.

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