Compounds with anti-inflammatory and anti allergy Series of glucocorticosteroids, Methods for preparing such Compounds, Pharmaceutical compositions comprising them, and combinations thereof, and therapeutic uses.Claim 1: wherein is a compound of General formula (1) wherein R1 is - (CH2) n - Z - N - (CH2) R3 where N and N are independently 0, 1 or 2； Z is a simple union or select between - S -, - or - OC (r4r5)； R3 is Selected from the group consisting of H, hal u00f3ge Oh, no, NS, CONH2 C1, C2 alquenilo alkyl - 6, 6 - 4, haloalquilo C1 -,Alquinilo C1 - and C2 - 4 alkyl and alkyl 6sulfonilo C1 - 6carbonilo； nr4r5, R4 and R5 are selected independently from the group consisting of 6 - alkoxy alkyl C1 and C1 - C3 - 6； 8 heterocicloalquilo cycloalkyl, aryl and heteroaryl C3 - 8,Each of which is optionally substituted with one or more Halogen Atoms or groups or oxo groups CN； and R2 is selected from the group consisting of: C1 - 8 linear or branched alkyl, alkoxy haloalquilo C1 C1 - 6 - 6, optionally substituted with one or more Atoms (or groups of Hal u00f3geno MR6； - (CH2), R6 is selected from the group consisting of cycloalkyl C3 - 8Heterocicloalquilo C3 - 8 arylalkyl C1 -, aryl, heteroaryl ariltio ariloxi 6,, and, each of which optionally substituted with one or more substituents selected from the group consisting of oxo Halogen, CN, Oh, NH2, CONH2, NO2, NHC (or H), linear or branched alkyl C1 - 6 haloalquilo, C1 - 6 linear or branched, linear or branched alkoxy C1 - 6 - 6, haloalcoxi C1 linear or branched.Hidroxialcoxi C1 - 6 - 6, haloalcoxi C1, C1 6carbonilo alkyl alkoxy -, alkyl - 6carboxilo C1, C1 and C1 - 6sulfanilo 6sulfonilo alkyl, alkyl - 6oxisulfonilo haloalquil C1, C1 - C3 aminosulfonilo 6sulfoniloxi, cycloalkyl, - 8, - 6 and heterocicloalquilo C3 heteroaryl,Where M is 0 or an integer between 1 and 3 and X and y are independently H or Halogen； and pharmaceutically acceptable salts thereof； provided that when R1 is a group CH2OH and R2 is alkyl or cycloalkyl
