Disclosed are methods of the treatment or prevention of chordoma which include the step of administering a yeast-based immunotherapeutic composition. The yeast-based immunotherapeutic composition preferably comprises a Brachyury antigen.本發明揭示治療或預防索脊瘤之方法,其包括投與以酵母菌為基礎之免疫治療組合物之步驟。以酵母菌為基礎之免疫治療組合物較佳包含短尾突變體抗原。