Humanized influenza monoclonal antibodies and methods of use thereof

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专利权人:

Inc.;Dana-Farber Cancer Institute

发明人:

Marasco, Wayne A.

申请号：

AU2016246065

公开号：

AU2016246065A1

申请日:

2016.04.08

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

The present invention provides structural determinants important for binding to the stem domain of the HA protein of influenza virus, and methods of use thereof for production of high affinity neutralizing influenza virus antibodies based upon these determinants. The present invention further provides tools for determining the efficacy of an influenza virus vaccine. The present invention further provides a molecular signature useful for determining the efficacy of an influenza virus vaccine in a subject, or for predicting prior immunologic exposure or antigen responsiveness to vaccine or influenza virus infection.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/