A drug infusion system located at least partially external to the patient having a pump and an external patient programmer control configured to allow adjustment of therapy. Adjustment may include setting, selecting and adjusting the transition period between drug delivery rates. The system can present to the patient an alert related to the adjustment and receive patient input information in response thereto. A patient response rule module is configured to apply a rule to the input information provided by a patient. For example, the patient response rule can be used to provide an insulin pump setting according to the patient response rule or to provide a setting, or to provide a setting that is proposed to the user. Other systems and methods are also described such as asking questions related to the adjustment of future therapy settings.
