Mucoadhesive polymer with vitamin B partial structure

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专利权人:

ティオマトリックス・フォルシュンクス・ウント・べラートゥンクス・ゲーエムベーハー;ティオマトリックス・フォルシュンクス・ウント・べラートゥンクス・ゲーエムベーハー;クローマ・ファルマ・ゲーエムベーハー

发明人:

ライエラー、ヨハネス

申请号：

JP2012531410

公开号：

JP6016234B2

申请日:

2010.09.29

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

Because of the formation of disulfide bridges with mucus glycoproteins, the mucoadhesive properties of polymeric compounds can be significantly improved by the covalent attachment of thiol substructures to them. By the transformation of free thiol groups on such polymers in disulfides with mercaptonicotinamides or mercaptopyridoxins these thiol groups become comparatively more reactive resulting in significantly improved mucoadhesive properties. Furthermore, polymers exhibiting disulfide partial structures with mercaptonicotinamides or mercaptopyridoxins do not need to be protected against oxidation. In addition, they show comparatively higher permeation enhancing properties.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/