THIOMATRIX FORSCHUNGS- UND BERATUNGS GMBH;CROMA PHARMA GMBH
发明人:
JOHANNES LEIERER
申请号：
IN3140DEN2012
公开号：
IN3140DEN2012A
申请日:
2012.04.12
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
Because of the formation of disulfide bridges with mucus glycoproteins, the mucoadhesive properties of polymeric compounds can be significantly improved by the covalent attachment of thiol substructures to them. By the transformation of free thiol groups on such polymers in disulfides with mercaptonicotinamides or mercaptopyridoxins these thiol groups become comparatively more reactive resulting in significantly improved mucoadhesive properties. Furthermore, polymers exhibiting disulfide partialstructures with mercaptonicotinamides or mercaptopyridoxins do not need to be protected against oxidation. In addition, they show comparatively higher permeation enhancing properties.
