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Materials for hydrophobic acrylic intraocular lenses
专利权人:
NOVARTIS AG
发明人:
LAREDO, WALTER R.
申请号:
ES12727022
公开号:
ES2537537T3
申请日:
2012.06.01
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A copolymeric material for an ophthalmic device formed by polymerization of a mixture comprising a) 40-80% (w / w) or greater of an aryl acrylic hydrophobic monomer of formula (I) ** Formula ** in which A it's H; B is (CH2) m, S (CH2) u, O (CH2) v u [O (CH2) 2] n; u is 1-4; v is 1-4; C is (CH2) w; m is 1-6; n is 1-10; Y is nothing, O, S or NR, provided that if Y is O, S or NR, then B is (CH2) m; R is H, CH3, CnH2n + 1 (n>; = 1-10), iso-OC3H7, C6H5 or CH2C6H5; w is 0-6, provided that m + w>; = <;= 8; and D is H, C1-C4 alkyl, C1-C4 alkoxy, C6H5, CH2C6H5, Br, F, Cl or I; b) 0.1-3.9% (w / w) of a macromer of formula (II) ** Formula ** in which R1 and R2 are independently -CH3, -CH2CH3, -CH2CH2CH2CH3, CH2CH2CH2CH3, -C6H5 , -CH2C6H5, - CH2CH2C6H5, -CH2CH2CH2C6H5, or -CH2CH2CH2CH2C6H5; R3 is H, CH3 or CH2CH3; z is 2-11; and x indicates the number of repeating units and determines the molecular weight of the macromer and is such that the macromer has a molecular weight of approximately 300 to approximately 3,500. c) 5-30% (w / w) of a siloxane monomer of formula (III) ** Formula **Un material copolimérico para un dispositivo oftálmico formado mediante polimerización de una mezcla que comprende a) el 40 - 80 % (p/p) o superior de un monómero hidrófobo acrílico de arilo de fórmula (I)**Fórmula** en la que A es H; B es (CH2)m, S(CH2)u, O(CH2)v u [O(CH2)2]n; u es 1 - 4; v es 1 - 4; C es (CH2)w; m es 1 - 6; n es 1 - 10; Y es nada, O, S o NR, a condición de que si Y es O, S o NR, entonces B es (CH2)m; R es H, CH3, CnH2n+1 (n >;= 1 - 10), iso-OC3H7, C6H5 o CH2C6H5; w es 0-6, a condición de que m+w >;=<;= 8; y D es H, alquilo C1-C4, alcoxi C1-C4, C6H5, CH2C6H5, Br, F, Cl o I; b) el 0,1-3,9 % (p/p) de un macrómero de fórmula (II)**Fórmula** en la que R1 y R2 son independientemente -CH3, -CH2CH3, -CH2CH2CH2CH3, CH2CH2CH2CH3, -C6H5, -CH2C6H5, - CH2CH2C6H5, -CH2CH2CH2C6H5, o -CH2CH2CH2CH2C6H5; R3 es H, CH3 o CH2CH3; z es 2 - 11; y x indica el número de unidades de repetició
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