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EXPRESSION OF PROTECTIVE ANTIGENS IN TRANSGENIC CHLOROPLASTS AND THE PRODUCTION OF IMPROVED VACCINES
专利权人:
UNIVERSITY OF CENTRAL FLORIDA;DANIELL, HENRY
发明人:
DANIELL, HENRY
申请号:
WO2002US41503
公开号:
WO03057834(A3)
申请日:
2002.12.26
申请国别(地区):
世界知识产权组织国际局
年份:
2003
代理人:
摘要:
Vaccines for conferring immunity in mammals to infective pathogens are provided, as well as vectors and methods for plastid transformation of plants to produce protective antigens and vaccines for oral delivery. The invention further provides transformed plastids having the ability to survive selection in both the light and the dark, at different developmental stages by using genes coding for two different enzymes capable of detoxifying the same selectable marker, driven by regulatory signals that are functional in proplastids as well as in mature chloroplasts. The invention utilizes antibiotic-free selectable markers to provide edible vaccines for conferring immunity to a mammal against Bacillus anthracis, as well as Yersina pestis. The vaccines are operative by parenteral administration as well. The invention also extends to the transformed plants, plant parts, and seeds and progeny thereof. The invention is applicable to monocot and dicot plants.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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