CHO, Young Shin,LEVELL, Julian Roy,LIU, Gang,SHULTZ, Michael David,VAN DER PLAS, Simon Cornelis
申请号：
ES14716934
公开号：
ES2651132T3
申请日:
2014.03.13
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
The compound according to formula (I): ** Formula ** wherein: R1 is hydrogen, methyl or ethyl； R2a and R2b join together to form a cyclopropyl ring； R3 and R4 are each independently hydrogen, methyl or ethyl or R3 and R4 are joined together to form cyclopropyl, cyclobutyl or oxetanyl； R5 and R6 are each independently hydrogen, deuterium, halo, -C (O) OCH3, C1-3 alkyl or C1-3 haloalkyl； R7 is ** Formula ** said ring A is a 6-membered heteroaryl ring having one to three nitrogen atoms； said ring B is a heteroaryl ring having one to four heteroatoms each independently selected from the group consisting of N, O and S； X is N or CH； each R8 eS independently hydrogen, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy or C1-3 haloalkoxy； n is 1 or 2； R9 is hydrogen, halo, C1-3 haloalkyl, optionally substituted C1-3 alkyl, optionally substituted C3-6 cycloalkyl, optionally substituted 5 or 6 membered heterocyclic, optionally substituted aryl, optionally substituted heteroaryl, -OR9a, -SO2 R9a, -C (O) NHR9a, -CH2R9b or CHCH3R9b provided that when X is N, R 9 is hydrogen, C1-3 haloalkyl, optionally substituted C1-6 alkyl, optionally substituted C3-6 cycloalkyl, optionally substituted aryl , optionally substituted heteroaryl, -SO2R9a or -C (O) NHR9a, wherein: said C1-6 alkyl is optionally substituted with one to three substituents each independently selected from the group consisting of: OH and phenoxy, and said cycloalkyl of C3-6, 5- or 6-membered heterocyclic, aryl and heteroaryl are each optionally substituted with one to three substituents each independently selected from the group consisting of: halo, hydroxyl, cyano, -NRR, C1-6 alkyl, halo C1-6 alkyl, C1-3 alkoxy and C1-3 haloalkoxy； R9a is optionally substituted C1-6 alkyl, C1-6 haloalkyl, optionally substituted C3-6 cycloalkyl, optionally substituted phenyl or optionally substituted heterocyclic, wherein: said C1-6 alkyl is optionally substituted with a C3-6 cycloalkyl , said C3-6 cycloalkyl and heterocyclic are optionally
