RABOISSON PIERRE JEAN-MARIE BERNARD,DE KOCK HERMAN AUGUSTINUS,HU LILI,SURLERAUX DOMINIQUE LOUIS NESTOR GHISLAIN,SIMMEN KENNETH ALAN,SALVADOR ODEN LOURDES,NILSSON KARL MAGNUS,ROSENQUIST ASA ANNICA KRIS
申请号：
SI200631188
公开号：
SI1912997T1
申请日:
2006.07.28
申请国别(地区):
SI
年份:
2012
代理人:
摘要：
Macrocylic compounds having inhibitory activity on the replication of the hepatitis C virus (HCV) of the general formula (I) X is N, CH and where X bears a double bond it is C； R1a and R1b are hydrogen, C3-7cycloalkyl, aryl, Het, C1-6alkoxy, C1-6alkyl optionally substituted with halo, C1-6alkoxy, cyano, polyhaloC1-6alkoxy, C3-7cycloalkyl, aryl, or with Het； or R1a and R1b together with the nitrogen to which they are attached form a 4 to 6 membered heterocyclic ring which may be optionally substituted； Het being a heterocyclic ring； L is a direct bond, &mdash；O&mdash；, &mdash；O&mdash；C1-4alkanediyl-, &mdash；O&mdash；CO&mdash；, &mdash；O&mdash；C(&boxH；O)&mdash；NR5a&mdash； or &mdash；O&mdash；C(&boxH；O)&mdash；NR5a&mdash；C1-4alkanediyl-； n is 3, 4, 5, or 6； p is 1, or 2； R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl； R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl, amino, mono- or diC1-6alkylamino； R4 is aryl or a saturated, a partially unsaturated or completely unsaturated 5 or 6 membered monocyclic or 9 to 12 membered bicyclic heterocyclic ring system wherein said ring system contains one nitrogen, and optionally one to three additional heteroatoms selected from O, S and N, and wherein the remaining ring members are carbon atoms； wherein said ring system may be optionally substituted； and pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I).
