The present invention discloses an application of peptide for treatment/prevention of hypertension and associated diseases, which means to administer an effective dosage of peptide or composition containing the peptide to an individual with hypertension for recovering the blood pressure of the individual to a normal blood pressure range or regulate the blood pressure of the individual to lower the blood pressure and thus achieve the effect of treatment or prevention of hypertension and associated diseases.本發明係揭露提供一種短胜肽用於治療/預防高血壓及其相關疾病之用途,意即藉由投予有效量之短胜肽或含有該短胜肽之組合物至一罹患高血壓之個體,係能夠使該個體之血壓恢復至正常血壓範圍內,或是調控該個體血壓,使之血壓下降,以達到治療或預防高血壓及其相關疾病之功效。