AMINOALKYL-SUBSTITUTED N-THIENYLBENZAMIDE DERIVATIVE

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专利权人:

ASTELLAS PHARMA INC.

发明人:

MIURA, MASANORI,三浦理宪,三浦理憲,KAGA, DAISUKE,加贺大辅,加賀大輔,WATANUKI, SUSUMU,四月朔日晋,四月朔日晉,HACHIYA, SHUNICHIRO,八谷俊一郎,八谷俊一郎,OKUDA, TAKAO,奥田崇男,奧田崇男,SATO, IPPEI,佐藤一平,佐藤一平,ISOMURA, MAI,矶村真衣,磯村真衣,TERAI, KAZUHIRO,寺居和宏

申请号：

TW101139423

公开号：

TW201323419A

申请日:

2012.10.25

申请国别(地区):

TW

年份:

2013

代理人:

摘要：

[Problem] To provide a compound that has an intestinal phosphate transporter (NPT-IIb) inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing hyperphosphatemia.[Means for Solution] The present inventors conducted thier studies on a compound that has an NPT-IIb inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing hyperphosphatemia. As a result, they created an aminoalkyl-substituted N-thienylbenzamide derivative which has NPT-IIb, inhibitory action, thereby completing the present invention. The aminoalkyl-substituted N-thienylbenzamide derivative of the present invention has an NPT-IIb inhibitory action and can be used as an agent for preventing and/or treating hyperphosphatemia.提供一種具有腸磷酸鹽轉運子(NPT-IIb)抑制作用且可用作為高磷酸鹽血症之治療及/或預防劑的活性成分之化合物。本發明人對具有NPT-IIb抑制作用且可用作為高磷酸鹽血症之治療及/或預防劑之活性成分的化合物進行研究。結果,產生一種具有NPT-IIb抑制作用的經胺基烷基取代之N-噻吩基苯甲醯胺衍生物,因而完成本發明。本發明之經胺基烷基取代之N-噻吩基苯甲醯胺衍生物具有NPT-IIb抑制作用且可用作為高磷酸鹽血症之治療及/或預防劑。

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/