THIOPHENE-SUBSTITUED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES农业专利-农业专业知识服务系统

发明人:: TONG, LING,董林,董林,YU, WENSHENG,俞文胜,俞文勝,KOZLOWSKI, JOSEPH A.,克斯洛斯基乔瑟夫A,克斯洛斯基喬瑟夫A,CHEN, LEI,陈蕾,陳蕾,SELYUTIN, OLEG,沙耶丁欧乐吉,沙耶丁歐樂吉,KIM, SEONG HEON,金圣宪,金聖憲,DWYER, MICHAEL,德耶麦可,德耶麥可,HU, BIN,胡宾,胡賓,ZHONG,

摘要：: The present invention relates to novel Thiophene-Substituted Tetracyclic Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, A, R2, R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Thiophene-Substituted Tetracyclic Compound, and methods of using the Thiophene-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.本發明係關於新穎的式(I)之噻吩取代之四環化合物:及其醫藥上可接受之鹽,其中A、A、R2、R3、R4及R5係如本文所定義。本發明亦係關於包含至少一種噻吩取代之四環化合物之組合物及使用該等噻吩取代之四環化合物治療或預防患者之HCV感染的方法。