LEONARD, JACK L.,SIMIN, KARL J.,LEONARD, DEBORAH M.
申请号：
CA3001125
公开号：
CA3001125A1
申请日:
2016.10.18
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The invention relates to the discovery of a vital new component of the Wnt pathway that regulates trafficking of ß-catenin to the cell nucleus and novel therapeutic approaches to cancer treatment. Disclosed herein is a previously unknown, essential component of the Wnt/ß-catenin signaling pathway that governs the quantity of ß-catenin delivered to the cell nucleus. This intracellular inhibitor of ß-catenin signaling (IBS) is transcribed from a second transcriptional start site adjacent to exon 3 of the Dkk3 gene and is required for early mouse development. IBS captures ß-catenin destined for the nucleus in a complex with ß-TrCP that is bound to the actin cytoskeleton and unavailable for nuclear translocation.
