An environment recognition guide system and method for guiding a movable medical equipment are disclosed. The environment recognition guide system includes a depth camera, an environment data storage device, and an object image recognition device. When the object image recognition device compares and determines an environment image pixel depth signal acquired by the depth camera matching predetermined object image pixel depth signals stored in the environment data storage device, the medical equipment is driven to move along a preset guide path. The movable medical equipment is further provided with collision protection function to prevent the medical equipment from collision with a front obstacle during the movement.