ENKE, HEIKE,LORENZEN, WOLFRAM,JAHNS, STEFAN,ENKE, DAN,NIEDERMEYER, TIMO,MOSCHNY, JULIA
申请号：
CA3060225
公开号：
CA3060225A1
申请日:
2018.05.09
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The invention relates to a compound, which comprises the cytotoxic agents microcystin and nodularin. More specifically, the invention is related to a modified microcystin and/or nodularin compound comprising one or more modified substrates, wherein one or more modified substrates comprise an anchor group directly accessible or transformable for use in conjugation chemistry (incl. click chemistry), for the attachment of a targeting moiety. This invention is in the field of cancer treatment. It is in the field of toxins for use in cancer treatment. The modified cytotoxic agents may be used for the therapy of various diseases.
