The present invention provides the preparation of a mixture of oligosaccharides or oligosaccharide analogues showing antithrombotic activity, a pharmaceutically acceptable salt of said oligosaccharide or mixture of oligosaccharide analogues, a mixture of said oligosaccharides or oligosaccharide analogues. Method, drug composition comprising a mixture of said oligosaccharides or oligosaccharide analogues, and prevention and / or treatment of thromboembolic diseases of said oligosaccharide or a mixture of oligosaccharide analogues as an endogenous tenase inhibitor Uses in the manufacture of drugs. [Selection diagram] None本発明は、抗血栓活性を示すオリゴ糖又はオリゴ糖同族体の混合物、前記オリゴ糖又はオリゴ糖同族体の混合物の薬学的に許容可能な塩、前記オリゴ糖又はオリゴ糖同族体の混合物の製造方法、前記オリゴ糖又はオリゴ糖同族体の混合物を含んでなる薬物組成物、並びに内因系テンナーゼ阻害剤として前記オリゴ糖又はオリゴ糖同族体の混合物の、血栓塞栓性疾患を予防及び/又は治療する薬物の製造における用途に関する。【選択図】なし