SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS
Nicole Cohen;Loren D. Walensky;Michelle L. Stewart
发明人:
Loren D. Walensky,Michelle L. Stewart,Nicole Cohen
申请号：
US13576116
公开号：
US20130035304A1
申请日:
2011.01.31
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.
