MEADOWS, CHEYNEY,FREEHAUF, KEITH ALAN,SIMMONS, ROBERT D
申请号：
NZ59855407
公开号：
NZ598554A
申请日:
2007.12.18
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
ABSTRACT - 598554 The disclosure relates to a transdermal liquid preparation for administration to cattle comprising: (a) a first and a second dermal penetration enhancer； (b) an aprotic primary solvent selected from the group consisting of a pyrrolidone solvent, N,N-dimethylacetamide, N,N-dimethylformamide, DMSO, acetone, glycerol formal ethyl lactate, glycol ethers, and/or mixtures thereof； and (c) a therapeutically effective amount of flunixin meglumine； wherein the first dermal penetration enhancer is menthol； and wherein the second dermal penetration enhancer is selected from the group consisting of terpenoids, saturated or unsaturated fatty acid esters or diesters of propylene glycol and glycerol, saturated or unsaturated fatty acids, saturated or unsaturated fatty alcohols, xylene, isopropyl myristate, and mixtures thereof, preferably the second dermal penetration enhancer is selected from the group consisting of D-limonene, propylene glycol dicaprylate/dicaprate, decanoic acid, decyl alcohol, oleic acid, or mixtures thereof.
