Pharmaceutical compositions comprising an active pharmaceutical ingredient, a high viscosity liquid carrier material, a hydrophobic solvent, and a hydrophilic solvent are disclosed. Also disclosed are methods of manufacturing and using the compositions. The compositions are suitable for use, e.g., as depot formulations.本發明揭示包含活性醫藥成分、高黏度液體載劑材料、疏水性溶劑及親水性溶劑之醫藥組成物。本發明亦揭示製造及使用該組成物之方法。該組成物適合作為例如儲積調製劑。