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Compound Inhibiting Activation of the Enzyme ERK 1/2 To Be Used In The Treatment Of Neurodegenerative Illnesses
专利权人:
Jordi Mestres Lopez;Elisabet Gregori Puigjane;Ana Jimenez Redondo;Marisol Montolio Del Olmo;Pilar Navarro Medrano
发明人:
Pilar Navarro Medrano,Elisabet Gregori Puigjane,Marisol Montolio Del Olmo,Ana Jimenez Redondo,Jordi Mestres Lopez
申请号:
US13699355
公开号:
US20130065966A1
申请日:
2010.05.24
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention relates to a compound of formula (I) for use as a medicine, in particular for use in the treatment of diseases mediated by the actvation of the protein kinase Erk1/2, such as neurogenerative illnesses like Alzheimer's and related dementia, epilepsy, Parkinson's disease, Huntington's disease, or stroke, and likewise relates to the pharmaceutical compositions containing said compound. The compound of formula (I) effectively inhibits the activation of the enzyme Erk1/2 induced by the tissue plasminogen activator (TPA) and also effectively inhibits the apoptosis generated by the β-amyloid peptide.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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