Systems and methods which implement a plurality of different imaging signatures in generating an image frame are shown. A first imaging signature may be configured for providing relatively high quality images with respect to subsurface regions of living tissue, for example, whereas a second imaging signature may be configured for providing relatively high quality images with respect to interventional instruments inserted into living tissue at a steep angle. Image sub-frames generated using each such different imaging signature are blended to form a frame of the final image providing a relatively high quality image of various objects within the volume being imaged.
