KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;한국화학연구원
发明人:
YUN, Chang Soo,윤창수,HWANG, Jong Yeon,황종연,HA, Jae Du,하재두,AHN, Sun Joo,안선주,KIM, Hyoung Rae,김형래,CHO, Sung Yun,조성윤,JUNG, Hee Jung,정희정,LEE, Kwangho,이광호,CHAE, Chong Hak,채종학,LEE, Chong Ock,이정옥,PARK, Chi Hoon
申请号：
KRKR2015/005118
公开号：
WO2015/194764A3
申请日:
2015.05.21
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a pyrimidine-2,4-diamine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for prevention or treatment of cancer comprising the same as an effective ingredient. A compound according to the present invention has the good effect of inhibiting anaplastic lymphoma kinase (ALK) activity, whereby a therapeutic effect on cancer cells having a anaplastic lymphoma kinase (ALK) fusion protein such as EML4-ALK, NPM-ALK, etc. can be enhanced and it is expected that a recurrence of cancer will be effectively inhibited. As such, the compound can be effectively used in a pharmaceutical composition for prevention or treatment of cancer.La présente invention concerne un dérivé de pyrimidine-2,4-diamine ou son sel pharmaceutiquement acceptable, et une composition pharmaceutique utilisable à des fins de prévention ou de traitement du cancer en contenant en tant que principe actif. Un composé selon la présente invention a pour effet bénéfique d'inhiber l'activité de la kinase ALK (anaplastic lymphoma kinase), grâce à quoi l'effet thérapeutique sur des cellules cancéreuses comportant une protéine de fusion de la kinase ALK, de type EML4-ALK, NPM-ALK, etc., peut être renforcé, avec une inhibition efficace attendue de toute rechute du cancer. C'est pourquoi ce composé peut être efficacement utilisé dans une composition pharmaceutique destinée à la prévention ou au traitement du cancer.본 발명은 피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 의한 화합물은 역형성 림프종 키나아제(ALK) 활성을 억제하는 효과가 우수하므로 이에 따른 EML4-ALK, NPM-ALK 등의 역형성 림프종 키나아제(ALK) 융합 단백질을 가진 암세포에 대한 치료효과가 향상될 수 있으며, 암의 재발을 막는데 효과적일 것으로 예상되므로 암의 예방 또는 치료용 약학적 조성물로 유용하게 사용될 수 있다.
