A sterile isolation drape that can be used to create a vertical boundary to the sterile field during hip fracture and similar surgeries. The invention includes a cutout region or opening in the drape that interfaces with an elongated, closed plastic tunnel. This closed tunnel can receive the lower part of the C-arm and allow it to extend into position with respect to the patient without entering the sterile field. A fluid reservoir can be located laterally on one or both sides of the tunnel region to allow trapping of body fluids such as blood without interfering with the entry of the C-arm. The drape can be weighted on the bottom so that the vertical portion remains substantially vertical during entry and exit of the C-arm. The weights can be fixed or removable. The drape can also have optional utility pouches in convenient locations.